Well, maybe not ever, but Bill Amend sometimes hits upon pure gold with his Foxtrot offerings. I just adore comics like this that don't cater to a particular audience but rather challenge the reader to step outside a comfortable norm.
I much prefer setup, huh?, wha'? to setup, setup, punchline.
If you 'get' the humour in this Foxtrot comic, you would also have had a good laugh at this portion of a previous Simpsons episode.
Hit the link below to decipher the second frame of the comic.
'M' is, well, M.
2.71828 is the numerical approximation of the natural logarithm, e.
r squared is r times r, or just rr.
(1/y) to the power of -1 is the inverse of an inverse, resulting simply in y.
The square root of x squared is x.
(Force/Acceleration) = Mass.
Ergo, you have 'Merry Xmas'.
As an aside, I found the force/acceleration bit particularly funny since it reminded me of three of the core engineering fundamentals I learned while in university:
F = MA
You can't push on a rope
Payday is on Friday